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What is Nembutal Powder and how is it used?

Nembutal (pentobarbital sodium) is a barbiturate that acts as a depressant, or sedative, used short-term to treat insomnia. Nembutal is also used as an emergency treatment for seizures, and to cause patients to fall asleep for surgery. Nembutal is available in generic form.

What are the side effects of Nembutal?

Common side effects of Nembutal include:

  • problems with memory or concentration,
  • excitement,
  • irritability,
  • aggression (especially in children or older adults),
  • confusion,
  • loss of balance or coordination,
  • nightmares,
  • nausea,
  • vomiting

Typical applications for pentobarbital are sedative, short term hypnotic, preanesthetic, insomnia treatment, and control of convulsions in emergencies. Abbott Pharmaceutical discontinued manufacture of their Nembutal brand of Pentobarbital capsules in 1999, largely replaced by the benzodiazepine family of drugs.

Pentobarbital can reduce intracranial pressure in Reye’s syndrome, treat traumatic brain injury and induce coma in cerebral ischemia patients. Pentobarbital-induced coma has been advocated in patients with acute liver failure refractory to mannitol.

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Pentobarbital (previously known as pentobarbitone in Britain and Australia) is a short-acting barbiturate typically used as a sedative, a preanesthetic, and to control convulsions in emergencies.  It can also be used for short-term treatment of insomnia but has been largely replaced by the benzodiazepine family of drugs. Nembutal Powder for sale

In high doses, pentobarbital causes death by respiratory arrest. It is used for veterinary euthanasia and is used by some US states and the Federal government of the United States for executions of convicted criminals by lethal injection.  In some countries and states, it is also used for physician-assisted suicide.

Pentobarbital was widely abused and sometimes known as “yellow jackets” due to the yellow capsule of the Nembutal brand. Pentobarbital in oral (pill) form is not commercially available

Pentobarbital can cause death when used in high doses. It is used for euthanasia for humans as well as animals. It is taken alone, or in combination with complementary agents such as phenytoin, in commercial animal euthanasia injectable solutions.

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Pentobarbital Sodium (CAS No. 57-33-0)
In the Netherlands, pentobarbital is part of the standard protocol for physician-assisted suicide for self-administration by the patient.  It is given in liquid form, in a solution of sugar syrup and alcohol, containing 9 grams of pentobarbital. This is preceded by an antiemetic to prevent vomiting.

It is taken by mouth for physician-assisted death in the United States states of Oregon, Washington, Vermont, and California (as of January 2016). The oral dosage of pentobarbital indicated for physician-assisted suicide in Oregon is typically 10 g of liquid.

In Switzerland, sodium pentobarbital is administered to the patient intravenously. Once administered, sleep is induced within 30 seconds, and the heart stops beating within 3 minutes. Oral administration is also used. A Swiss pharmacist reported in 2022 that the dose for assisted suicide had been raised to 15 grams because with lower doses death was preceded by a coma of up to 10 hours in some cases.


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